Asthma exacerbations: a molecular dichotomy between antiviral and pro‐inflammatory responses revealed
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چکیده
منابع مشابه
Asthma exacerbations: a molecular dichotomy between antiviral and pro-inflammatory responses revealed
» . . .it is possible to dissociate antiviral from pro-inflammatory responses simply by inhibiting the p65 subunit of NF-kB. . . « costs for individuals with asthma. They are the main cause of hospitalizations and are poorly controlled by current medication. It is therefore disappointing that we still know so little about the mechanistic details of asthma exacerbations. In this issue of EMBO Mo...
متن کاملInteractions between innate antiviral and atopic immunoinflammatory pathways precipitate and sustain asthma exacerbations in children.
Severe asthma exacerbations in children requiring hospitalization are typically associated with viral infection and occur almost exclusively among atopics, but the significance of these comorbidities is unknown. We hypothesized that underlying interactions between immunoinflammatory pathways related to responses to aeroallergen and virus are involved, and that evidence of these interactions is ...
متن کاملAssociation between respiratory viruses and asthma exacerbations
This is an open-access article distributed under the terms of the Creative Commons Attribution NonCommercial License (http://creativecommons.org/ licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Editorial Korean J Pediatr 2014;57(1):26-28 http://dx.doi.org/10.3345/kjp.2014.57.1.26 pISSN...
متن کاملAsthma Exacerbations
Asthma exacerbations are common in patients with uncontrolled asthma and carry a considerable burden of morbidity. Despite treatment guidelines by the National Asthma Education and Prevention Program (NAEPP) Expert Panel Report 3 (EPR-3) and the Global Initiative for Asthma (GINA), patients continue to experience uncontrolled asthma and thus are at increased risk for severe exacerbations. Asthm...
متن کاملViruses and asthma exacerbations.
For many years general opinion has been that upper respiratory viruses were the cause of the common cold but were able to produce serious complications only in infants, the elderly, and immunocompromised subjects. Although a connection between upper respiratory infections and asthma had long been recognised, the potential importance of the association was probably underestimated until relativel...
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ژورنال
عنوان ژورنال: EMBO Molecular Medicine
سال: 2012
ISSN: 1757-4676,1757-4684
DOI: 10.1002/emmm.201202032